MOLECULAR MECHANISMS AND THERAPEUTIC POTENTIAL OF NATURAL FLAVONOIDS IN DIABETIC NEPHROPATHY: MODULATION OF INTRACELLULAR DEVELOPMENTAL SIGNALING PATHWAYS

Recognized as a common microvascular complication of diabetes mellitus (DM), diabetic nephropathy (DN) is the principal cause of chronic end-stage renal disease (ESRD).Patients with diabetes have an approximately 25% risk of developing progressive renal disease.The underlying principles of DN control targets the dual outcomes of blood glucose regul

Background: Complicated crown fracture is a tooth fracture that involve enamel, dentine and pulp.The incidence of complicated crown fracture ranges from 2% to 13% of all dental injuries and the most commonly involved teeth are the maxillary central incisors.Various treatment modalities are available depending on the clinical, physiological and radi

In many temperate countries there is a very obvious seasonal variation in mortality, so winter death rates are 10-25% higher than in summer.The main causes of death in winter are cardiovascular pathologies, cerebrovascular, circulatory and respiratory.We believe that if we establish a relationship between alternating warm and cold seasons and exerc

Due to phonological and morphological processes, there has been an excessive reduction of case forms in the development of the German case system.Thus, syncretism is frequently found in Standard German and even more so in German dialects, where the process of case levelling is more advanced.In this sense, here analysing dialects permits a diachroni

The article is devoted to the assessment of technologies, tools and methods for ensuring financial security of the banking system in modern conditions of business digitalization and informational transformation.Relevance of the topic is caused by the fact that financial security of the banking business entirely depends not only on digital tools of